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- W2360419530 abstract "Objective To investigate the effects of aminoguanidine (AG),a selective inhibitor of inducible nitric oxide synthase on proliferation and apoptosis of MFC stomach cancer in mice. Methods The mice stomach carcinoma cell line MFC was implanted subcutaneously in kunming mice. Mice were randomly divided into 4 groups: control group (saline solution),MMC group (mitomycin,twice a week 0.7 mg/kg ),AG group (AG,150 mg·kg-1·d-1) and combined treatment of both MMC and AG group. All drugs were given by intraperitoneal injection. The mice were sacrificed after 2 weeks and the tumors were processed for histological examination. In addition,sera were collected and nitrite levels were tested using Greiss assay. The expression of proliferating cell nuclear antigen (PCNA) in tumors was detected by immunohistochemical method and apoptosis in tumors was measured by TdT mediated biotinyated dUTP nick end labeling (TUNEL) method. The ultrastructural features of apoptosis cells were observed under electromicroscope. Results Compared with the negative control group,the growth of the orthotopically implanted tumor was significantly inhibited by AG and the inhibitory rate was 47.1%. Expression of PCNA in AG treated group was lower than that in the control group,but no significant difference in apoptosis index (AI) was found. Typical morphological changes of apoptosis in tumor cells were not observed in AG treated group. Conclusion AG can significantly inhibit tumor growth by inhibiting the production of NO,but can not promote the apoptosis of MFC cells." @default.
- W2360419530 created "2016-06-24" @default.
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- W2360419530 date "2004-01-01" @default.
- W2360419530 modified "2023-09-25" @default.
- W2360419530 title "Effect of aminoguanidine on proliferation and apoptosis of stomach cancer MFCs in mice" @default.
- W2360419530 hasPublicationYear "2004" @default.
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