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- W2360422757 abstract "To investigate neurobiological mechanisms of opiate dependence and abstinence, the contents of β endorphine in brain areas related with rewarding and withdrawal syndrome in rats were determined in morphine dependent and abstinent rats by radioimmunoassay. Results:(1)In morphine dependent group,the β EP contents in nucleus accumbens(Acc),periaqueductal gray(PAG),locus coeruleus(LC) and nucleus arcuatus hypothalami(ARH) were significantly lower than that in control group (P0.05 or 0.01).(2)In morphine abstinent group,the β EP contents in Acc and ARH were significantly lower than that in control group (P0.05 or 0.01),and were not significantly different from that in morphine dependent group;however,the β EP contents in VTA, PAG and LC were not different from that in control group, and were significantly higher than that of morphine dependent group(P0.05 or 0.01).Conclusion:There is a change of the β endorphin contents in brain nuclei associated with rewarding and withdrawal syndromes during the development of morphine dependence and abstinence." @default.
- W2360422757 created "2016-06-24" @default.
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- W2360422757 date "1999-01-01" @default.
- W2360422757 modified "2023-09-23" @default.
- W2360422757 title "CHANGES OF THE β-ENDORPHIN CONTENT IN SOME BRAIN NUCLEI IN MORPHINE DEPENDENT AND ABSTINENT RATS" @default.
- W2360422757 hasPublicationYear "1999" @default.
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