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- W2360425238 abstract "Objective To investigate the clinical significance of circulating endothelial cells(CEC)and their expression of the phosphorylation state of serine 910 of focal adhesion kinase(FAKps910)and heat-shock protein 70(HSP70)in hemorrhagic fever of renal syndrome(HFRS) patients.Methods The study selected 20 healthy volunteers and 50 HFRS patients,the latter of which were with mild(17),moderate(20) and severe(13) conditions,respectively.CEC count and the expression of FAKps910 and HSP70 were determined by Flow Cytometry.Results CEC count and the expression of HSP70 were all significantly increased during the first four stages of HFRS and returned to normal range in the recovery stage.The increases of CEC count and the expression of HSP70 were associated with the deterioration of disease conditions during the late fever or hypotension stage,and reached to peak in severe HFRS.The level of FAKps910 increased in the early febrile stage and decreased in the late febrile or hypotension stage.The decrease of FAKps910 was associated with aggravated condition in the late fever or hypotension stage of HFRS.Conclusions CEC count and the expression of FAKps910 and HSP70 have prognostic values for HFRS patients.The increases of CEC count and FAKps910 expression reflect the injuries of endothelial cells,which is similar to the mechanism of EC injuries mediated by hantavirus acting on β3 intergrin.The increase of HSP70 expression may play an important role in protecting EC among HFRS patients." @default.
- W2360425238 created "2016-06-24" @default.
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- W2360425238 date "2011-01-01" @default.
- W2360425238 modified "2023-09-27" @default.
- W2360425238 title "Expression of focal adhesion kinase and HSP70 in circulating endothelial cells in hemorrhagic fever of renal syndrome" @default.
- W2360425238 hasPublicationYear "2011" @default.
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