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- W2360425596 abstract "Objective:To estimate the efficiency of preimplantation genetic diagnosis for reciprocal and Robertsonian translocations using the array comparative genomic hybridization(aCGH) technology. Methods:Cell biopsy was carried out on the cleavage-stage embryos(Day3). Single cell was firstly lysed and DNA amplified by whole genome amplification(WGA). WGA product was then processed by aCGH. Embryos with normal and balanced chromosomes were transferred. Results:Total of 90 cases of clinical PGD oocyte retrieval cycles included 58 cases of reciprocal balanced translocation and 32 cases of Robertsonian translocation. Total of 528 embryos were biopsied, of which 518(98.1%) embryos got the confirmed diagnoses. Single embryo transfer was adopted with the clinical ongoing pregnancy rate of 46.8%. The ongoing pregnancy rate of the reciprocal balanced translocation in fresh cycles was 38.7%, and that in freezed cycles 45.0%. The Robertsonian translocation pregnancy rate in freezed cycles was 61.5%. Conclusions:Application of aCGH in the reciprocal and Robertsonian translocation PGD can obviously improve clinical outcomes." @default.
- W2360425596 created "2016-06-24" @default.
- W2360425596 creator A5039670824 @default.
- W2360425596 date "2014-01-01" @default.
- W2360425596 modified "2023-09-26" @default.
- W2360425596 title "Application of Micro-Array Comparative Genomic Hybridization on Preimplantation Genetic Diagnosis for Chromosome Translocation" @default.
- W2360425596 hasPublicationYear "2014" @default.
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