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- W2360428013 abstract "Objective To explore toxic effects of Aroclor1254 on early development stage of zebra fish embryo.Method The embryos of 10 hours post fertilization(10 hpf) were kept in water containing Aroclor1254.Changes of morphology were observed and in situ hybridization test was conducted.Results We found that Aroclor1254,a commercial PCB mixture,altered the spontaneous rotating movement of zebra fish embryo,and investigated the mechanism.Untreated control embryos started rotation within the chorion spontaneously from 23hpf,and the frequency reached peak level at 26hpf.After that,rotation was decreased in frequency and could not be observed at 32 hpf.The action of Aroclor1254 was markedly attenuated by inhibitors of tyrosinase(melanin synthesizing enzyme).The area of tyrosinase expression near hindbrain was extended by Aroclor1254 exposure around 26hpf.Conclusions These studies provide a greater molecular understanding of the mechanism of action of Aroclor1254 and its potential to impact neuron system and hypothyroid." @default.
- W2360428013 created "2016-06-24" @default.
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- W2360428013 date "2010-01-01" @default.
- W2360428013 modified "2023-09-24" @default.
- W2360428013 title "PCB Mixture Increases the Spontaneous Rotating Movement in Early Zebra Fish Embryo" @default.
- W2360428013 hasPublicationYear "2010" @default.
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