Matches in SemOpenAlex for { <https://semopenalex.org/work/W2360429058> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2360429058 abstract "Objective The aim was to investigate the inhibition and radiosensitization effect of topotecan(TPT) on cervical cancer cell line HeLa.Methods The inhibition of TPT on HeLa was evaluated by MTT assay and the 24-hour 50% inhibitory concentration(IC50) was applied in further experiments.Its radiosensitization was investigated by flow cytometry(FCM) and clone formation assay.Results The inhibition of TPT on HeLa cell was time-dependent and dose-dependent.The IC50 at 24 hours of TPT was 8 μg/mL,significantly lower than that at 48 hours(2.6 μg/mL) and 72 hours(0.8 μg/mL)(P0.05).The apoptosis rate at 24 hours of the chemotherapy-only group,radiation-only group and the combination group by FCM were 14.4%,45.7% and 68.2%,respectively,and the difference among them was significant(P0.05).Further clone formation assay showed that TPT could significantly enhance the inhibition of radiation on HeLa,which showed the radiosensitization of TPT on the tumor cell.After fitting the curve of HeLa cell surviving by single hit multi target model,the sensitization enhancement ratio of TPT at 24 hours and 48 hours were 1.167 and 1.344 respectively.Conclusion Topotecan has the effect of inhibition and radiosensitization on HeLa cell,which was both time-dependent and dose-dependent.These may be related with the inhibition of post-injury repair ability of TPT." @default.
- W2360429058 created "2016-06-24" @default.
- W2360429058 creator A5019703931 @default.
- W2360429058 date "2008-01-01" @default.
- W2360429058 modified "2023-09-23" @default.
- W2360429058 title "The inhibition and radiosensitization of topotecan on cervical cancer cell line HeLa" @default.
- W2360429058 hasPublicationYear "2008" @default.
- W2360429058 type Work @default.
- W2360429058 sameAs 2360429058 @default.
- W2360429058 citedByCount "0" @default.
- W2360429058 crossrefType "journal-article" @default.
- W2360429058 hasAuthorship W2360429058A5019703931 @default.
- W2360429058 hasConcept C126322002 @default.
- W2360429058 hasConcept C1491633281 @default.
- W2360429058 hasConcept C153911025 @default.
- W2360429058 hasConcept C185592680 @default.
- W2360429058 hasConcept C190283241 @default.
- W2360429058 hasConcept C202751555 @default.
- W2360429058 hasConcept C206684579 @default.
- W2360429058 hasConcept C2776694085 @default.
- W2360429058 hasConcept C2777366897 @default.
- W2360429058 hasConcept C2777752497 @default.
- W2360429058 hasConcept C2779707156 @default.
- W2360429058 hasConcept C2780783641 @default.
- W2360429058 hasConcept C2781209748 @default.
- W2360429058 hasConcept C509974204 @default.
- W2360429058 hasConcept C54355233 @default.
- W2360429058 hasConcept C552990157 @default.
- W2360429058 hasConcept C553184892 @default.
- W2360429058 hasConcept C55493867 @default.
- W2360429058 hasConcept C71924100 @default.
- W2360429058 hasConcept C81089528 @default.
- W2360429058 hasConcept C81885089 @default.
- W2360429058 hasConcept C86803240 @default.
- W2360429058 hasConcept C98274493 @default.
- W2360429058 hasConceptScore W2360429058C126322002 @default.
- W2360429058 hasConceptScore W2360429058C1491633281 @default.
- W2360429058 hasConceptScore W2360429058C153911025 @default.
- W2360429058 hasConceptScore W2360429058C185592680 @default.
- W2360429058 hasConceptScore W2360429058C190283241 @default.
- W2360429058 hasConceptScore W2360429058C202751555 @default.
- W2360429058 hasConceptScore W2360429058C206684579 @default.
- W2360429058 hasConceptScore W2360429058C2776694085 @default.
- W2360429058 hasConceptScore W2360429058C2777366897 @default.
- W2360429058 hasConceptScore W2360429058C2777752497 @default.
- W2360429058 hasConceptScore W2360429058C2779707156 @default.
- W2360429058 hasConceptScore W2360429058C2780783641 @default.
- W2360429058 hasConceptScore W2360429058C2781209748 @default.
- W2360429058 hasConceptScore W2360429058C509974204 @default.
- W2360429058 hasConceptScore W2360429058C54355233 @default.
- W2360429058 hasConceptScore W2360429058C552990157 @default.
- W2360429058 hasConceptScore W2360429058C553184892 @default.
- W2360429058 hasConceptScore W2360429058C55493867 @default.
- W2360429058 hasConceptScore W2360429058C71924100 @default.
- W2360429058 hasConceptScore W2360429058C81089528 @default.
- W2360429058 hasConceptScore W2360429058C81885089 @default.
- W2360429058 hasConceptScore W2360429058C86803240 @default.
- W2360429058 hasConceptScore W2360429058C98274493 @default.
- W2360429058 hasLocation W23604290581 @default.
- W2360429058 hasOpenAccess W2360429058 @default.
- W2360429058 hasPrimaryLocation W23604290581 @default.
- W2360429058 hasRelatedWork W1501122410 @default.
- W2360429058 hasRelatedWork W2141604403 @default.
- W2360429058 hasRelatedWork W2161598352 @default.
- W2360429058 hasRelatedWork W2349455651 @default.
- W2360429058 hasRelatedWork W2350328463 @default.
- W2360429058 hasRelatedWork W2356914696 @default.
- W2360429058 hasRelatedWork W2357345756 @default.
- W2360429058 hasRelatedWork W2357570302 @default.
- W2360429058 hasRelatedWork W2359143792 @default.
- W2360429058 hasRelatedWork W2362773407 @default.
- W2360429058 hasRelatedWork W2366138009 @default.
- W2360429058 hasRelatedWork W2366152309 @default.
- W2360429058 hasRelatedWork W2371359768 @default.
- W2360429058 hasRelatedWork W2380367885 @default.
- W2360429058 hasRelatedWork W2383603371 @default.
- W2360429058 hasRelatedWork W2383798804 @default.
- W2360429058 hasRelatedWork W2384152368 @default.
- W2360429058 hasRelatedWork W2392909611 @default.
- W2360429058 hasRelatedWork W2589358319 @default.
- W2360429058 hasRelatedWork W3030653065 @default.
- W2360429058 isParatext "false" @default.
- W2360429058 isRetracted "false" @default.
- W2360429058 magId "2360429058" @default.
- W2360429058 workType "article" @default.