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- W2360432815 abstract "Objective: To study the changes of plasma ET, Ag Ⅱ and PGI-2 in patients during open heart surgery undergoing cardiopulmonary Bypass (CPB) and discuss the clinical significance of the dynamic changes of three vasoactive substances. Method: With radioimmunoassay, the plasma of ET AgⅡ and PGI-2 (end product 6 keto PGF 1α ) were measured in 30 open heart surgery patients at 7 timepoints preoperation at the onset of CPB, 30 minutes after onset of CPB, aortic cross clamp removal, at the cessation of CPB and 2 and 24 hours after operation, respectively. Result: At the onset of CPB, ET level was higher than preoper ative value (P0.05), increased gradually during the CPB, reaching thepeak concentrations at the cessation of CPB (P0.01), decreased 2 hours and 24 hours after operation, but its level was still higher (P0.05). AgⅡ level was higher than preoperative value (P0.05), decreased 30 minutes after CPB but increased at the removal of aortic cross clamp, reaching the peak concentrations at the cessation of CPB (P0.01). The 6 keto PGF 1α level increased significantly (P0.01), after that time point, its level decreased gradually. Conclusion: ET and Ag Ⅱ levels increased significantly, the 6 keto PGF 1α level decreased during CPB. Therefore, to add antagonist of ET and AgⅡ or the synthesizer of PGI-2 during CPB Should be beneficial to patients." @default.
- W2360432815 created "2016-06-24" @default.
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- W2360432815 date "2004-01-01" @default.
- W2360432815 modified "2023-09-23" @default.
- W2360432815 title "Changes of Plasma ET,AgII and PGI_2 LevelsIn Patients undergoing Open Heart Surgery" @default.
- W2360432815 hasPublicationYear "2004" @default.
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