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- W2360433699 abstract "Objective:To investigate the correlation of the serum leukotrienes(LT)B4level with the risk of acute myocardial infarction(AMI)and the arachidonate 5-lipoxygenase activating protein(ALOX5AP)gene SG13S114T/A polymorphism in Chinese Han population in Sunan region.Method:The serum LTB4levels(M/ IQR)and the polymorphism in the ALOX5AP gene SG13S114T/A were measured by enzyme-linked immunosorbent assay and polymerase chain reaction and restriction fragment length polymorphism analysis respectively in 262 AMI patients(AMI group)and 132subjects without coronary heart disease(control group).Result:The ALOX5AP gene SG13S114T/A polymorphism existed in both groups.The serum level of LTB4in AMI group(477.97/370.52ng·L-1)was significantly higher than that in control group(200.57/236.65ng·L-1)(P 0.01),and was positively correlated with smoking(P0.01,R2=0.039)but unrelated with gender,hypertention,diabetes and dyslipidemia.There was no significant difference in the serum LTB4levels among AA,AT and TT genotypes of the ALOX5AP gene SG13S114T/A(517.98/392.00ng·L-1 vs 492.31/427.55ng·L-1 vs 495.29/398.54ng·L-1)in AMI patients,and also in the same gender AMI subgroup patients.Conclusion:In Chinese Han population in Sunan region,polymorphism of ALOX5AP gene SG13S114exists in patients with AMI and subjects without coronary heart disease.The elevated serum levels of LTB4is related with the risk of AMI, but unrelated with ALOX5AP gene SG13S114polymorphism." @default.
- W2360433699 created "2016-06-24" @default.
- W2360433699 creator A5079891332 @default.
- W2360433699 date "2014-01-01" @default.
- W2360433699 modified "2023-09-23" @default.
- W2360433699 title "Correlation of the serum leukotriene B4level with the risk of acute myocardial infarction and the ALOX5AP gene SG13S114T/A polymorphism" @default.
- W2360433699 hasPublicationYear "2014" @default.
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