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- W2360436601 abstract "Objective To reduce the antigen of allogeneic dermis and investigate its availability for comoposite transplantation. Methods Split-thickness skin grafts from common swine were divided into two groups with or without glutaraldehyde cross-linking treatment. Then the cross-linked sADM (sADM1) and non cross-linked sADM (sADM0) were embedded subcutaneously in rabbits and transplanted after scar was excised off. The histological observation was performed to determine the results of sADM1 and sADM0 after transplantation. Results The sADM0 with severe immune response were infiltrated by autologenous tissue cells in the early phase after embeded in rabbits. Furthermore, the degeneration and contraction of sADM0 were observable. By comparison, the sADM1 with less histocompatibility, slight immune response, and unobservable degeneration and contraction, showed comparatively complete appearance and histological structure till 30 weeks after embedment. sADM overlaid with auto-over thin split-thickness skin (OTS) were compositely transplanted onto the wounds. The survival rate was about 78.9% similar to that of auto-thin split-thickness skin (TTS). In the group of sADM0 overlaid with OTS, the survived grafts showed an early immune response and observable contraction, and appeared like OTS after transplantation. In the group of sADM1- overlaid with OTS, the survived grafts with slight early immune response and contraction locked flat and touched soft as TTS. Conclusion The sADM1 used as dermal substitute of composite skin could retard the early immune response and improve the result of OTS transplantation, but couldn't completely prevent delayed heterogeneous rejection, indicating the sADM need to be improved." @default.
- W2360436601 created "2016-06-24" @default.
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- W2360436601 date "2007-01-01" @default.
- W2360436601 modified "2023-09-24" @default.
- W2360436601 title "Fabrication and Observation of Clinical Application of Xenogeneic Acellular Dermal Matrix" @default.
- W2360436601 hasPublicationYear "2007" @default.
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