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- W2360436727 abstract "Objective To explore the epidemiological characteristics and clinical features of respiratory syncytial virus(RSV) and human metapneumovirus(hMPV) in children infected with acute lower respiratory tract infection(ALRTI) in Changsha.Methods A total of 1,165 nasopharyngeal aspirates(NPAs) specimens were collected from children with ALRTI hospitalized in the Pediatric Medicine Center of Hunan Provincial People's Hospital between September,2007 and August,2008.Genes of RSV and hMPV in the NPAs were detected by RT-PCRs.The epidemiological characteristics,clinical feature and laboratory results were compared among children with ALRTI caused by RSV,by hMPV and by both.Results RSV was detected in 315 of 1,165 patients(27.04%),with 64.1% younger than one year old,while hMPV was identified in 76 of these patients(6.52%),with 63.15% younger than one year old.RSV infection occurred throughout a year,with a peak from December of the first year to February of the next year,while hMPV infection was mainly detected from March to April.The RSV infected children were more likely to have tachypnea than the hMPV infected(P0.05).There were no significant differences between RSV and hMPV infected children regarding the incidence of fever,wheezing,vomiting or diarrhea,nor were the abnormal changes of WBC,CRP,ALT or CK-MB(P0.05).Image examination indicated that both infections mainly showed interspersed solidification and interstitial damage in the lung.Large patchy shadows in the lung and pleural lesions were rarely detected.Fourteen patients were identified to be simultaneously infected with RSV and hMPV,with a co-infection rate of 1.20%(14/1165).The incidence of cyanosis in the co-infection cases was significantly higher than that in the pure RSV infection,while the incidences of wheezing,tachypnea,vomiting,diarrhea and elevated CRP,ALT and CK-MB did not indicate any significant difference between co-infection and both single-infections(P0.05).Children with single-infection of hMPV were more likely to get fever than children with single-infection of RSV and children with co-infection,while children with co-infection more likely had elevated WBC than both those with single-infections(P0.05).The course,hospitalization days and prognosis were not statistically different among single-infections and co-infection(P0.05).Conclusions Both RSV and hMPV are important pathogens of ALRTI in children in Changsha.They are similar in many ways,such as prevalence season,clinical feature and image changes.RSV infection is more likely to lead to tachypnea,while hMPV infection is more likely to lead to fever.Co-infection with hMPV may aggravate respiratory symptoms of RSV infection." @default.
- W2360436727 created "2016-06-24" @default.
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- W2360436727 date "2012-01-01" @default.
- W2360436727 modified "2023-09-26" @default.
- W2360436727 title "Analysis of Epidemiological Characteristics and Clinical Features of Respiratory Syncytial Virus and Human Metapneumovirus in Children with Acute Lower Respiratory Tract Infection in Changsha" @default.
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