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- W2360449785 abstract "Objective To explore the effect of sound conditioning on antioxidant enzymes of cochlea in guinea pigs. Methods Forty male albino guinea-pigs were equally randomized into 4 groups.The animals were either:(A)kept in quiet cages(control);(B)exposed to conditioning noise of a 0.5 kHz octave band(90 dB for 6 h/day for 10 days);(C)exposed to conditioning noise(B)followed by exposure to the higher level noise(105 dB for 4 h)after 5 days'rest;or(D)exposed to high level noise(105 dB for 4 h)directly.Animals were killed at the end of the experiment,and the cochleas were dissected to determine the levels of malondialdehyde(MDA)and three antioxidant enzymes.Results The level of MDA in group D was significantly higher than those of the other groups(144.19±4.59,147.12±4.51,163.76±4.83,187.11±6.14 for group A、B、C、D respectively,P0.05).After exposure to noise,the activities of superoxide dismutase(SOD)and gluta- thione peroxidase(GSH-Px)were enhanced,and more significant in group C when compared to group D(282.20±22.46 vs 243.95±16.53;32.72±2.24 vs 26.84±2.22 respectively,P0.05).High level noise exposure alone decreased catalase activity,while with sound conditioning followed by a brief rest showed an increase in catalase activity over control group (63.18±4.59,65.93±4.41,82.34±4.66 and 45.60±4.88 for greup A、B、C、D respectively,P0.05).Conclu- sion The treatment of conditioning noise results in enhancements of antioxidant activity of cochlea." @default.
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- W2360449785 date "2008-01-01" @default.
- W2360449785 modified "2023-09-25" @default.
- W2360449785 title "Effect of Sound Conditioning on Antioxidant Enzymes of Cochlea in Guinea Pigs" @default.
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