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- W2360465113 abstract "Objective To investigate the effects of a-lipoic acid(ALA) on expression of transforming growth factor-fJl(TGF-β1) and connective tissue growth factor(CTGF) in the kidney of streptozocin(STZ) -induced diabetic rats.Methods Diabetes was induced by intraperitoneal injection of 60 mg/kg STZ in rats,and the diabetic rats were randomly divided into DN group(n = 9,treated with physiological saline) and ALA group(n = 8,treated with ALA 35 mg/kg by intraperitoneal injection every other day).The rats of control group(n = 10) were given vehicle citrate buffer in the same dose.Rats were sacrificed at 12 weeks and 20 weeks of study.The three groups were compared in terms of blood glucose,creatinine clearance,urine protein,renal pathological changes.The concentration of reduced glutathione(GSH),glutathione disulfide(GSSG) and the ratio of GSH/ GSSG were measured by spectrophotometry,and the expression of TGF-βi and CTGF was detected by immunohistochemical staining.Results Compared with control group,the blood glucose level and urine protein in DN rats were significantly increased;the creatinine clearance decreased;and the GSH levels were decreased,the GSSG levels increased,the ratio of GSH/GSSG were increased;the expression of TGF-βl and CTGF in kidney was greatly increased.Compared with DN group,the urine protein level,creatinine clearance and the intensity of GSSG in ALA group were significantly decreased;the levels of GSH and the ratio of GSH/GSSG were increased;the expression of TGF-β1 and CTGF decreased and the morphological changes were ameliorated significantly.Conclusion ALA can suppress oxidative stress,reverse histological changes of glomerulosclerosis and attenuates the overexpression of TGF-β1 and CTGF in diabetic nephropathy in rats." @default.
- W2360465113 created "2016-06-24" @default.
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- W2360465113 date "2011-01-01" @default.
- W2360465113 modified "2023-09-23" @default.
- W2360465113 title "α-lipoic acid attenuates TGF-β1 and CTGF overexpression in STZ-induced diabetic nephropathy" @default.
- W2360465113 hasPublicationYear "2011" @default.
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