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- W2360469070 abstract "The pharmacokinetics of naproxen sustained release tablets (500 mg, qd) was investigated together with a conventional preparation (250 mg, bid) after multiple oral administration in eight healthy human subjects using an open, randomized two way crossover experimental design. Based on the area under the plasma concentration time curve ( AUC ), the two tablet formulations are judged to be bioequivalent, with a relative bioavailability of 97.0% for the sustained release formulation. The sustained release formulation reached significantly delayed mean peak plasma levels compared with the conventional one. But there was no statistically significant difference for other pharmacokinetic parameters, including C max , C min , AUC , t 1/2 and the fluctuation index ( FI ) between the two preparations." @default.
- W2360469070 created "2016-06-24" @default.
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- W2360469070 date "1999-01-01" @default.
- W2360469070 modified "2023-09-25" @default.
- W2360469070 title "MULTIPLE DOSE PHARMACOKINETIC AND BIOAVAIL ABILITY STUDIES OF ORAL SUSTAINED RELEASE AND CONVENTIONAL FORMULATIONS OF NAPROXEN IN HEALTHY VOLUNTEERS" @default.
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