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- W2360469376 abstract "Objective: To investigate the effects of simvastatin on cardiac hypertrophy mediated by calcineurin in rats with pres-sure-overload. Methods: Sprague-Dawley rats were randomly allocated into three groups: the sham-operated groups (n=10), model groups (n=10) and simvastatin-treated groups (n=10). The model of pressure overload was established by abdominal arota constriction. At the end of the treatment period, the left ventricular weight/body weight ratio, left ventricular mass, wall thickness (by echocardiogra- phy), myocardial content of CaN and CaNmRNA (by westernblot and RT-PCR), all were assessed. Results: ① The left ventricular weight/body weight ratio of model group and simvastatin-treated group, was significantly higher than that of the sham-operated group (P0.05); compared with model group, the ratio was lower in simvastatin-treated group (P0.05). ② There was a higher level of CaN and CaNmRNA expression in model group and simvastatin-treated group than that in sham-operated group (P0.05); and the level of CaN and CaNmRNA expression in model group was significantly higher than that in simvastatin-treated group (P0.05). Conclusion: The present data suggests that simvastatin may inhibit calcineurin-mediated hypertrophy in rats with pressure-overload." @default.
- W2360469376 created "2016-06-24" @default.
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- W2360469376 date "2009-01-01" @default.
- W2360469376 modified "2023-09-26" @default.
- W2360469376 title "Inhibiting Effects of Simvastatin on Pressure Overload-induced Cardiac Hypertrophy Mediated by Calcineurin" @default.
- W2360469376 hasPublicationYear "2009" @default.
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