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- W2360469968 abstract "Objective To explore genes related to early-stage liver metastasis from colorectal cancer and provide the theoretical basis for the early diagnosis of liver metastasis from colorectal cancer.Methods The RT2 ProfilerTM PCR Array Human Tumor Metastasis(PAHS-028A) chip was used to screen differential genes in the primary tumor and the liver metastases.Results It was found that the following genes were expressed at significantly higher levels in the primary tumors of colorectal cancer than in the liver metastatic nodules:ACTB,APC,CTNNA1,NR4A3,MMP10,CTSL1,RB1,HPSE,ETV4,GNRH1,CDKN2A,KISS1R,IL8RB,ITGA7,ITGB3,DENR,RPSA,CXCR4,MYCL1,NME2,PNN,SMAD2,4,MMP11,SRC,RORB,SSTR2,SYK,TCF20,MMP3,TIMP2,3,4 and TIPM1.The following genes were expressed higher in liver metastases than in the primary tumor:MMP9,FN1,CST7,CCL7 and MGAT5.Conclusion Screening for genes related to early-stage liver metastasis genes may provide basis for making gene chips of early-stage liver metastasis from colorectal cancer." @default.
- W2360469968 created "2016-06-24" @default.
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- W2360469968 date "2011-01-01" @default.
- W2360469968 modified "2023-09-26" @default.
- W2360469968 title "The Study on Genes Associated with Early-stage Liver Metastasis after Colorectal Cancer Surgery" @default.
- W2360469968 hasPublicationYear "2011" @default.
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