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- W2360470523 abstract "The pathology of ulcerative colitis shows the chronic inflammation of colonic mucosa and submucosa, its precise etio-pathogensis remains unclarified. Fermented rye bran has been shown in vitro and in vivo to inhibit the adhesion of Helicobacter pylori (H. pylori) to gastric mucosa, and protect the mice against H. pylori infection. Aims: To investigate whether the fermented rye bran can protect the model mice receiving dextran sulfate sodium (DSS) from colitis. Methods: Colonic inflammation in the mice was induced by exposure to 3.5% DSS. Some mice received a combination of DSS and fermented rye bran. The clinical features including weight loss, rectal bleeding and diarrhea, and the histological changes of colonic mucosa were obseved. Results: The mice exposed to DSS and fermented rye bran showed late onset of the illnese and milder clinical symptoms, no diarrhea occurred during the period of observation. Histologically, the colonic mucosal inflammation in the mice receiving DSS and fermented rye bran was much less severe than that in the mice receiving DSS only. Conclusions: Fermented rye bran can somehow protect against the development of DSS-induced colitis in mice. Further studies are needed to clarify the mechanisms of its action." @default.
- W2360470523 created "2016-06-24" @default.
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- W2360470523 date "2004-01-01" @default.
- W2360470523 modified "2023-09-24" @default.
- W2360470523 title "Protective Effects of Fermented Rye Bran against Mice Colitis Induced by Dextran Sulfate Sodium" @default.
- W2360470523 hasPublicationYear "2004" @default.
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