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- W2360481273 abstract "Objective This study aims to investigate whether the change of ventricular Ang Ⅱ and BNP levels is involved in the reverse effect of perindopril and carvedilol on ventricular hypertrophy. Methods Twenty 15 week-old male SHRs were divided into three groups: perindopril group ( n =6,8 mg/kg·d -1 ),carvedilol group ( n =7,4 mg/kg·d -1 ) and sham group ( n =7). In each group drugs or equal volume of distill water were administered respectively for 6 weeks by gavage. We also used eight age matched WKY as a control group. We measured angiotensin Ⅱ (Ang Ⅱ) and B type natriuretic peptide(BNP) level in rat left ventricular and plasma by high performance liquid chromatography-radioimmunoassay technique (HPLC-RIA) and radioimmunoassay assay(RIA). Results (1)Perindopril and carvedilol decrease the blood pressure and LV/BW ratio after six weeks treatment ( P 0.05);(2) Perindopril significantly decrease the ventricular Ang Ⅱ level ( P 0.05),but markely increased plasma Ang Ⅱ level ( P 0.05);(3) Carvedilol significantly decrease plasma and ventricular Ang Ⅱ level ( P 0.05);(4) Both perindopril and carvedilol decrease ventricular and plasma BNP level ( P 0.05). Conclusion Perindopril and carvedilol reverse left ventricular hypertrophy which was in associated to the decreases in ventricular Ang Ⅱ level;BNP level might serve as a therapeutic index for reversal of ventricular hypertrophy." @default.
- W2360481273 created "2016-06-24" @default.
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- W2360481273 date "2004-01-01" @default.
- W2360481273 modified "2023-09-26" @default.
- W2360481273 title "Perindopril and Carvedilol on Ventricular Ang II and BNP" @default.
- W2360481273 hasPublicationYear "2004" @default.
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