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- W2360494812 abstract "Objective: To investigate the inhibitory effect and the mechanism of celecoxib,a selective COX-2 inhibitor,combined with fluorouracil on the growth of pancreatic cancer cell line SW1990.Methods: The experiment was divided into the control group,the fluorouracil group,the celecoxib group and the two drugs combined group,and the different concentrations of the drug were acting on pancreatic cancer cell lines SW1990.MTT assay was used to detect the growth inhibition rate of cells in each group,and to explore produce the bestcell growth inhibition of drug concentration.Flow cytometry was used to detect the impact of different drug effects on cell cycle.The expressions of Survivin cells in each group was measured by RT-PCR.Results: Fluorouracil,celecoxib inhibited the growth of SW1990,and the survival rate of the cells decreased with the increasing of the concentration of the drug.The two-drug combination group had more pronounced inhibition of cell growth.The celecoxib group,the fluorouracil group and the two-drug combination group increased significantly compared with that in the control group cells in G0/G1 phase proportion and significantly reduced proportion of cells in S and G2/M phase.RT-PCR results showed that the fluorouracil group,the celecoxib group and the combined group can down-regulate the expression of Survivin,a joint group of the most obvious.Conclusion: Celecoxib combined with fluorouracil inhibit the growth of pancreatic cancer SW1990 cells,which may be related to down the expression of Survivin to induce apoptosis and cell cycle arrest." @default.
- W2360494812 created "2016-06-24" @default.
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- W2360494812 date "2013-01-01" @default.
- W2360494812 modified "2023-09-22" @default.
- W2360494812 title "The Inhibitory Effect of Celecoxib Combined with Fluorouracil on SW1990 Pancreatic Cancer Cells Line" @default.
- W2360494812 hasPublicationYear "2013" @default.
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