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- W2360512009 abstract "To investigate the toxic effects of atmospheric particle size on bioactivities,the sensitivity of two cell lines A549 and HUVECs to atmospheric particles was studied using PM10-2.5,PM2.5-0.1 and PM0.1 collected from suburban Beijing.In vitro A549 and HUVEC cells were exposed to different concentrations of particles for 24 h,and then the cells' viability was measured by MTT assay.The Lactate dehydrogenase(LDH) level in the supernatant culture medium was determined by LDH Kit.Under treatment with PM10-2.5,PM2.5-0.1 and PM0.1 for 24 h,the viability of both cells lines decreased with increasing doses.PM10-2.5,PM2.5-0.1 and PM0.1 increased LDH release through a dose-dependent manner.At the same concentration level,the cytotoxicity of PM2.5-0.1 and PM0.1 was significantly stronger than that of PM10-2.5.Particles with the same size caused slightly stronger cytotoxicity on HUVEC cells than on the A549 cells.The cytotoxicity of fine and ultrafine particles was stronger than that of the coarse particles." @default.
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- W2360512009 date "2012-01-01" @default.
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- W2360512009 title "Toxic Effects of Ambient Particles on Human Lung Epithelial and Umbilical Vein Endothelial Cells" @default.
- W2360512009 hasPublicationYear "2012" @default.
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