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- W2360512076 abstract "AIM: To study the effect of GM1 ganglioside (GM1) on learning and memory disorders in rats with brain radiation. METHODS: 60 rats with brain irradiation by γ ray at the dosage of 7 Gy·d -1 for 6 days, then were divided into 3 groups: 20 rats were injected GM1 daily (GM1 group), 20 rats NS (NS group),and other 20 rats no any treatment (no treatment group). Another 20 rats were set as a normal rat group. The learning and memory ability of the rats was measured with Morris water maze, and histopathologic changes were also observed. RESULTS: The latency reached to platform shortened significantly in GM1 group in comparison with NS group and the no treatment group, but longer than normal rat group. The percentages of swim distance in platform quadrant in GM1 group were higher than those in NS group and the no treatment group,but lower than those in the normal rat group. Their histopathologic changes were mitigated in GM1 group compared with NS group. CONCLUSIONS: GM1 ganglioside shows a neuropotective effect on learning and memory impairment in rats with brain radiation." @default.
- W2360512076 created "2016-06-24" @default.
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- W2360512076 date "2003-01-01" @default.
- W2360512076 modified "2023-09-23" @default.
- W2360512076 title "Neuroprotective effect of GM1 ganglioside on learning and memory impairment in rats with brain radiation" @default.
- W2360512076 hasPublicationYear "2003" @default.
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