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- W2360516240 abstract "Objective: To detect the expression of receptors of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human cholangiocarcinoma tissue as well as paired normal bile duct tissue derived from surgically resected margins and cholangiocarcinoma cell line (QBC939) and explore their significance. Methods: The expressions of TRAIL receptors mRNA were detected by In sith hybridization histochemistry(ISHH). Results: Both of the death receptor, DR-4 and DR-5, was detectable in all of the cholangiocarcinoma tissues as well as paired normal bile duct tissue derived from surgically resected margins and cholangiocarcinoma cell line. Only 3 expressions of the DcR-1 (3/52) and 7 expressions of the DcR-2 (7/52) were detected in human cholangiocarcinoma tissues. The expression of DcR-1 and DcR-2 was not detected in cholangiocarcinoma cell line (QBC939) and DcR-1 and DcR-2 were highly expressed in all of paired normal bile duct tissue derived from surgically resected margins. Conclusion: The expression level of TRAIL receptors are various in human cholangiocarcinoma tissue as well as paired normal bile duct tissue derived from surgically resected margins. These findings suggest that expression of different receptors may play an important role in the apoptosis regulation of human cholangiocarcinoma." @default.
- W2360516240 created "2016-06-24" @default.
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- W2360516240 date "2004-01-01" @default.
- W2360516240 modified "2023-09-28" @default.
- W2360516240 title "Expression and significance of the receptors of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human cholangiocarcinoma" @default.
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