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- W2360526484 abstract "Objective:To discuss the ulceration and inflammation duration of a rat model of 2,4,6—trinitrobenzenesulfonic acid(TNBS)/ethanol—induced ulcerative colitis and how to build sustainable and stable rat model of chronic ulcerative colitis.Method:Seventy SD rats were divided randomly into 3 groups:normal group,model groups A and B.Model groups A and B were used TNBS/ ethanol to induce rat model of ulcerative colitis.Rats of model group A were given enema at a time while model group B were given enema every other 7 days to repeat molding,continued to eighth weeks.8 rats of model groups A and B were killed in second week,fifth week and eighth week after model making,then colonic lesions gross score and colon tissue pathology score were evaluated.Results:Compared with normal group,the weight,colonic lesions gross score and colon tissue pathology score of model group A were significantly different in second week(P0.01) and had no significant difference in fifth week and eighth week(P0.05) after model making.Model group B were significantly difference in second week,fifth week and eighth week(P0.05 orP0.01)after model making.Conclusion:Using TNBS/ethanol method every week can successfully create sustainable and stable rat model of chronic ulcerative colitis." @default.
- W2360526484 created "2016-06-24" @default.
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- W2360526484 date "2013-01-01" @default.
- W2360526484 modified "2023-09-25" @default.
- W2360526484 title "Discussion on Establishment Method of Rats Model of Chronic Ulcerative Colitis" @default.
- W2360526484 hasPublicationYear "2013" @default.
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