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- W2360542285 abstract "Objective To investigate the cellular rejection mechanisms of allogeneic hepatocyte transplantation intraperitoneally and the immunifaction of augmentor of liver regeneration (ALR) in acute liver failure (ALF) induced by D-galactosamine (D-gal). Methods ALF rats were induced by D-gal. HcT was received 24 h after intoxication intraperitoneally, and the rats were divided into 5 groups randomly. Group I received normal saline (NS), groupⅡ received hepatocytes, group Ⅲ received hepatocytes and CsA, group Ⅳ received hepato-cytes and ALR, and groupⅤ received ALR. The survival rate, the pathohistological examination of transplanted hepatocytes and liver, as well as the positive rates of CD4, CD8, and CD68 in greater omentum of all rats were observed. Results Survival rate of group Ⅳ was higher than that of groupⅠ (66.7% vs 0%, P=0.001), while there was no significant difference among other groups was similar. Rate of positive d1-2 CD68 in group Ⅱwere higher those that of group I and Ⅳ; rate of positive and Ⅱ d1-2 CD4 and CD8 group I were higher than those of group Ⅳ and Ⅴ; rate of positive d1-2 CD4 in group Ⅱwas higher than that of group Ⅲ. The rate of positive d1-2 CD4, CD8, and CD68 was lower than that of d14 in group Ⅳ; the rate of positive d1-2 CD68 was higher than that of d14 in group Ⅱ. Conclusion HcT plus ALR increase the survival rate of ALF rats intoxicated with D-gal. Allogeneic hepatocyte transplantation evokes CD4-, CD8-, and CD68-mediated cell immunity. ALR can suppress the cytoimmunity effectively, thus improve liver histology and promote proliferation of transplanted hepatocytes." @default.
- W2360542285 created "2016-06-24" @default.
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- W2360542285 date "2007-01-01" @default.
- W2360542285 modified "2023-09-24" @default.
- W2360542285 title "The role of augmentor of liver regeneration in cytoimmunity of allogeneic hepatocyte transplantation" @default.
- W2360542285 hasPublicationYear "2007" @default.
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