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- W2360560744 abstract "Objective To investigate the transport characteristics of praeruptorin in Caco-2 cell model.Methods The Caco-2 cell monolayer model was used to investigate the bidirectional transport of praeruptorin.The transport amount of drug was determined by HPLC method and calculated its apparent permeability coefficients(Papp).The impact of time and drug concentration on the bidirectional transport was then evaluated.Results The transport amount of praeruptorin was increased in the Caco-2 cell model within 120 min along with the increases of time and drug concentration.The Papp values for apical(AP) to basolateral(BL) or BL to AP were between 2.0×10-6 cm/s and 5.0×10-6 cm/s,with Papp(BL-AP) /Papp(AP-BL) less than 1.5.Conclusion Praeruptorin was a drug with relatively bad absorption,which absorbed mainly by passive diffusion approach through intestinal tract." @default.
- W2360560744 created "2016-06-24" @default.
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- W2360560744 date "2012-01-01" @default.
- W2360560744 modified "2023-09-23" @default.
- W2360560744 title "The absorption and transport characteristics of praeruptorin in Caco-2 cell model" @default.
- W2360560744 hasPublicationYear "2012" @default.
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