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- W2360583721 abstract "Objective:To analyze clinical efficacy and safety of biapenem in patients with hematological malignancy.Method:A total of 60malignant diseases patients combined with infection and were collected and randomly divided into biapenem group and control group.Biapenem was used as 0.3g(gram)every 8hours,intravenously and imipenem/cilastatin was use as 1g every 6hours,intravenously.And pathogenic bacteria was detected at the same time.Result:Thirty patients were enrolled into biapenem group,while 28patients were enrolled in control group with 2patients excluded for diagnosed as fungal infection with fungemia.The overall effective rate of biapenem group and control group was 66.7%and 71.4%,respectively.The effective rate of bacterial culture positive of two groups was 70.0%and 72.7%.The effective rate of bacterial culture negative was 65.0% and 70.6%.The effective rate of agranulocytic group was 52.2% and 68.2%.The effective rate in patients with agranulocytosis more than 10days was 53.8%and 58.3%,while agranulocytosis less than 10days was 50.0% and 80.0%.The effective rate of in patients with non-agranulocytosis was 71.4%and 83.3%.There were no statistical differences in the above parameters between two groups.And there was no statistical difference in adverse events(6.7% vs 10.7%).Conclusion:Biapenem has the similar clinical efficacy and safety compared to imipenem/cilastatin in hematological malignancy patients with infection,but has less gastrointestinal adverse events relatively.It is an economical and effective antibiotic." @default.
- W2360583721 created "2016-06-24" @default.
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- W2360583721 date "2014-01-01" @default.
- W2360583721 modified "2023-09-26" @default.
- W2360583721 title "The efficacy and safety of biapenem in hematological malignancies with severe infections" @default.
- W2360583721 hasPublicationYear "2014" @default.
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