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- W2360587709 abstract "Objective: To study the effect and mechanism of serum containing Pd-E on cultured hypertrophy cardiomyocytes stimulated by ET-1.Methods: Using the cultured neonatal rat ventricular myocyte,the cardiomyocyte size,pulsating frequency and c-Jun protein expression were examined.Results: Serum containing Pd-E had the effect of decreasing cardiomyocyte cell size,pulsating frequency,the level of c-jun of cardiomyocyte which increased after ET-1 stimulation.Conclusion: The reason of the effect of Pd-E might be associated with its effect of Ca~(2+) antagonistic action and modulating the expression of some immediate-early genes which play important role in the mitogen-activated protein kinase pathway.The striking ability of Pd-E to inhibit the effects of ET-1 on cadiomytocyte hypertrophy suggests that it could be an effective therapeutic drug in treating the contractile defects associated with cardiac hypertrophy and failure." @default.
- W2360587709 created "2016-06-24" @default.
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- W2360587709 date "2006-01-01" @default.
- W2360587709 modified "2023-09-23" @default.
- W2360587709 title "Study on Effect of Serum Containing Pd-E on Cultured Hypertrophy Cardiomyocytes Stimulated by ET-1" @default.
- W2360587709 hasPublicationYear "2006" @default.
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