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- W2360604689 abstract "Objective To investigate the distribution of acquired resistance genes,genetic markers of mobile genetic elements and their relationship in multidrug-resistant Klebsiella pneumonia(MDR-KPN).Methods 47 strains of MDR-KPN were collected from 6 hospitals in Hangzhou and Huzhou from August 2008 to May 2010 and 74 kinds of acquired resistance genes and 24 sorts of genetic markers of mobile genetic elements were detected by PCR.Index cluster analysis was performed to investigate their associativity. Results In 47 MDR-KPN strains,it is checked out for 5 acquired beta-lactam-resistance genes,6 acquired aminoglycoside-resistance genes,3 acquired quinolone-resistance genes,6 other acquired resistance genes,2 genetic markers of conjugal plasmids,2 genetic markers of transposons,4 genetic markers of insertion sequences,1 genetic marker of integron,1 genetic marker of prophages.Two clusters that A and B were divided by index cluster analysis depending on positive genes.Conclusion Index cluster analysis showed that the correlation existed closely between acquired resistance genes and mobile genetic elements.The characteristic of this group of strains was acquired resistance genes(TEM-1 and KPC) were induced by mobile genetic elements(Class 1 integrons,insertion sequences: IS26,ISEcpl,ISKpn6,resistance plasmid trbC)." @default.
- W2360604689 created "2016-06-24" @default.
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- W2360604689 date "2012-01-01" @default.
- W2360604689 modified "2023-09-27" @default.
- W2360604689 title "The investigation of index cluster analysis based on Klebsiella pneumonia acquired resistance genes and mobile genetic elements of multidrug-resistant" @default.
- W2360604689 hasPublicationYear "2012" @default.
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