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- W2360609124 abstract "Objective To prepare gliclazide (GZ) hydroxypropyl β cyclodextrin (HP β CD) inclusion complexes in order to enhance its aqueous solubility. Methods Inclusion complexes, prepared using 3 different methods of spray drying, freeze drying, and grinding, were identified by phase solubility analysis, infrared spectrophotometry, thermal analysis, and determination of the limited ammonium concentration. Results The HP β CD inclusion complexes could be prepared by using the 3 different methods. The ratio of host/guest molecules was 1∶1. Ammonium residues were detected in inclusion complexes prepared by the freeze dried method. Conclusion The inclusion complexes can be prepared by the spray drying and grinding methods. The solubility of gliclazide can be significantly increased in the inclusion complexes." @default.
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- W2360609124 date "2004-01-01" @default.
- W2360609124 modified "2023-09-25" @default.
- W2360609124 title "Preparation of gliclazide-hydroxypropyl-β-cyclodextrin inclusion complexes" @default.
- W2360609124 hasPublicationYear "2004" @default.
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