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- W2360615678 abstract "Objective To investigate the role of PTEN,P16 and P27 in the expression of breast cancer,and to explore the significance of clinic pathology.Methods The expressions of PTEN,P16 and P27 in 80 case of breast cancer and 30 case of mammary fiber adenoma were detected by means of immunocytochemistry,and the relationship with lymphatic metastasis was analyzed.Results The results showed that the positive expression rate of PTEN,P16 and P27 were 53.75%(43/80),36.25%(29/80),45.00%(36/80),as well as negative expression rate were 46.25%(37/80),63.75%(51/80),55.00%(44/80).Compared with the tissue of mammary fiber adenoma,the positive expression rate of breast cancer was significantly lower(P 0.01).The positive expression rate of non-lymphatic metastasis was significantly higher(P 0.05).Conclusions The expression level of the all detected markers in breast cancer is significantly lower than the control group and the positive rate of non-lymphatic metastasis is significantly higher than lymphatic metastasis.As a result,PTEN,P16 and P27 are prognosis factors for breast cancer,which can be used as the indicators to estimate the prognosis of breast cancer." @default.
- W2360615678 created "2016-06-24" @default.
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- W2360615678 date "2013-01-01" @default.
- W2360615678 modified "2023-09-27" @default.
- W2360615678 title "Expression and Clinicopathological Significance of PTEN,P16 and P27 in Breast Cancer" @default.
- W2360615678 hasPublicationYear "2013" @default.
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