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- W2360629478 abstract "Objective To study the dynamic changes of expression of HoxB5 mRNA and its effects on lung development in premature rats with chronic lung disease (CLD). Methods Eighty premature rats were selected and divided randomly into experimental group (n=40) and control group (n=40). CLD in neonatal premature rats was induced by hyperoxia exposure (FiO2=0.90). The dynamic changes of radical alveolar counts (RAC) were observed and the expression of HoxB5 mRNA in lung tissues were measured by reverse transcription polymerase chain reaction (RT-PCR) assay. Results There were no differences in RAC and HoxB5 mRNA expression between experimental and control group within 3 days after birth(P0.05). However, RAC and the HoxB5 mRNA expression in CLD group were significantly lower than those in control group(P0.05)on 7th and 14th days, and both decreased to the nadir on the 21st day(P0.01). The expression of HoxB5 mRNA was positively correlated with RAC (P0.01). Conclusions HoxB5 mRNA expression in lung tissue decreases with the prolonging of hyperoxia duration. Its low level is closely related to the disorder of lung development in neonates with CLD." @default.
- W2360629478 created "2016-06-24" @default.
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- W2360629478 date "2007-01-01" @default.
- W2360629478 modified "2023-09-24" @default.
- W2360629478 title "Expression and effect of HoxB5 mRNA in premature rats with hyperoxia-induced chronic lung disease" @default.
- W2360629478 hasPublicationYear "2007" @default.
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