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- W2360665292 abstract "Objective To observe the effects of ligustrazine and edaravone on free radicals and cytokines in rats with sepsis. Methods 40 Sprague-Dawley rats were randomly divided into 4 groups, sham operation group (group A), controlled operation group (group B), ligustrazine group (group C), ligustrazine and edaravone group (group D). Rats in group B, C, D were made as sepsis models through appendix ligation and puncture, and received subcutaneous injection of 20 mg/kg lactate levofloxacin 15 min before and 3 h after operation. Accompanied with lactate levofloxacin, 15 mg/kg ligustrazine was used in group C, and 15 mg/kg ligustrazine plus 5 mg/kg edaravone were used in group D. Blood and liver were taken from rats in all groups 18 h after operation. The activity of hydroxyl radical (·OH) in blood and liver was detected, and the concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), and interleukin-6 (IL-6) in blood were detected. Pathological changes of liver were observed by microscope and electron microscope. Results Cloudy swelling, pyknosis, and extension of endoplasmic reticulum in hepatocytes were observed in microscope and electron microscope in group B. There were on obvious pathological changes in group C and group D. The activity of·OH in blood and liver, and the concentrations of TNF-α and IL-6 in blood were significantly higher in group B than in group A (P0.01), and were significantly lower in group C and group D than in group B (P0.05 or P0.01). There were no significant differences of ·OH activity and TNF-α and IL-6 concentrations in blood between group C and group D (P0.05). The activity of·OH in liver in group D was significantly lower than that in group C (P0.01). There were no significant differences of IL-2 concentration in blood among the four groups (P0.05). Conclusion The activity of·OH in blood and liver, and the concentrations of TNF-α and IL-6 in blood were decreased in rats with sepsis after being treated by ligustrazine and edaravone, which can suppress inflammatory reaction and protect hepatic function." @default.
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- W2360665292 date "2009-01-01" @default.
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- W2360665292 title "Effects of ligustrazine and edaravone on free radicals and cytokines in rats with sepsis" @default.
- W2360665292 hasPublicationYear "2009" @default.
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