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• W2360690048 abstract "Objective To explore the role of vascular endothelial growth factor (VEGF) and VEGF polymorphisms in the pathogenesis of secondary pulmonary hypertension (PH) caused by congenital heart disease (CHD). Methods The type of CHD with left to right shunt was differentiated by echocardiography. The grade of PH was defined that the mean pulmonary artery pressure (MPAP) was 21 - 30 mmHg as mild PH, 31- 50 mmHg as moderate PH, and 50 mmHg as severe PH, respectively. Serum VEGF concentration with enzyme-linked immunosorbent assay was detected in 27 children with CHD complicating PH (PH group), 21 children with CHD non-complicating PH (non-PH group) and 25 healthy control subjects (control group), respectively. DNA genome was extracted from peripheral blood leucocytes, and polymerase chain reaction (PCR) was employed to amplify a 208bp fragment in exon 8 including 936 C/ T mutation in 3' untranslated region of the VEGF gene. The frequency of VEGF 936 C/ T genotype was analyzed with the method of restriction fragment length polymorphism (RFLP) in all children of three groups. Results (1) The level of serum VEGF in PH group was significantly higher than those in either non-PH or control groups (F0.05 for both) . There was no significant difference in the level of serum VEGF between latter two groups (P0.05) . (2) The level of serum VEGF was significantly higher in moderate to severe PH group than that in mild group (P0. 05). (3) No significantly difference in the frequency of VEGF 936C/T genotype was observed among PH group, non-PH group and control group (P 0.05 for all) . (4) The level of serum VEGF in CC genotype was significantly higher than that in CT genotype among all children of three groups (P0.05 for all). Conclusions It is suggested that VEGF probably plays an important role in the formation and progress of PH in children with CHD. VEGF 936T allele seems to lead to lower level of serum VEGF. However, the correlation between the polymorphisms of VEGF 936C/T genotype and the pathogenesis of secondary PH caused by CHD remained unknown, further investigation with a larger sample size will be required." @default.
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• W2360690048 date "2006-01-01" @default.
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• W2360690048 title "Role of vascular endothelial growth factor and its gene polymorphisms in the pathogenesis of secondary pulmonary hypertension caused by congenital heart disease" @default.
• W2360690048 hasPublicationYear "2006" @default.
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