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- W2360692004 abstract "[Objective]To explore the interrelationship and mechanism among osteoblastogenesis,adipogenesis and osteoclastogenesis in the bone marrow microenvironment from ovariectomized rat model of osteoporosis.[Method]Sixteen healthy female SD rats,3 months old,were randomly divided into two groups(n=8 each): sham group and OVX group.The osteoporotic rat model was established by bilateral ovariectomy.Fourteen weeks after ovariectomized,the bone mineral density(BMD) of femur and the fourth lumbar was measured by DXA.QRT-PCR were used for mRNA levels of RUNX2,PPARγ,OPG and RANKL in bone marrow cells.The number of adipocytes in the paraffin sections of bone tissues of proximal tibia and the third lumbar were measured with HE staining.The protein expression for OPG and RANKL in bone tissues of proximal tibia were measured by immunohistochemical staining.[Result]Compared with the sham group,BMD in the lumbar vertebra and femur from ovariectomized rats significantly decreased(P0.05).The mRNA level of RUNX2 in bone marrow from the OVX rat femur increased statistically compared with the sham group(P0.05).Compared with the sham guoup,The mRNA level of PPARγ also increased statistically in the OVX(P0.05).The number of adipocytes in the tibia and the third lumbar vertebra were greater in the OVX group than in the sham group(P0.05).Compared with the sham guoup,the mRNA level of RANKL in bone marrow from the femur and the protein expression for RANKL in the tibia were higher in the OVX group(P0.05),and the ratio of OPG/RANKL were lower in both mRNA and protein(P0.05).But no significant differences was found for the mRNA and the protein of OPG between the two groups(P0.05).[Conclusion]The ovariectomized rats exhibited loss of bone mass.This may be caused by the imbalances among osteoblastogenesis,adipogenesis and osteoclastogenesis in the bone marrow microenvironment." @default.
- W2360692004 created "2016-06-24" @default.
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- W2360692004 date "2013-01-01" @default.
- W2360692004 modified "2023-09-28" @default.
- W2360692004 title "Changes in RUNX2PPARγ and OPGRANKL expression in the bone marrow microenvironment from ovariectomized rats" @default.
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