Matches in SemOpenAlex for { <https://semopenalex.org/work/W2360702910> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2360702910 endingPage "32" @default.
- W2360702910 startingPage "526" @default.
- W2360702910 abstract "To evaluate the effect of Avastin and adenovirus-thymidine kinase/ Ganciclovir (Ad-TK/GCV) suicide gene system on nasopharyngeal carcinoma in vivo and in vitro.The expression of vascular endothelial growth factor (VEGF) by CNE1 cell line was detected by VEGF ELISA. The effect of Avastin and Ad-TK/GCV on CNE1 cell was detected by methyl thiazolyl tetrazolium (MTT) assay. Flow cytometry analysis and Hoechst 33342 staining were adopted to explore the killing mechanism of Ad-TK/GCV. The nude mice models of CNE1 cell xenografts were established. After intra-tumoral injection of PBS, Avastin, Ad-TK/GCV, Ad-Lac-Z/GCV and Ad-TK/GCV + Avastin, tumor volume was measured and tumor inhibitory rate was calculated. Then the tumors were removed and subjected to histological examination.CNE1 cells could produce VEGF. Avastin had no direct effect on CNE1 cells. The killing effect of Ad-TK/GCV increased with the increase of Ad-TK multiple of infection and the prodrug concentration, which was enhanced by the existence of bystander effect. Compared with control group, the death cell rate (P = 0.000) and apoptosis cell rate (P = 0.000) had significant difference. The study in vivo showed the tumors treated with Avastin, Ad-TK/GCV and Ad-TK/GCV + Avastin grew slowly compared with control. Tumor volume of treated groups was significantly smaller than that of control (all P < 0.05 or P = 0.000). Tumor weight of treated groups was significantly lower than that of control (all P = 0.000). The histological examination showed local necrosis in Ad-TK/GCV group and Ad-TK/GCV + Avastin group, poor angiogenesis in Avastin group and Ad-TK/GCV + Avastin group.Avastin had no direct effect on CNE1 cells in vitro. Ad-TK/GCV suicide gene system killed NPC cells by inducing cell necrosis and apoptosis, which could be enhanced by the existence of bystander effect. Avastin and Ad-TK/GCV suicide gene system could inhibit the growth of NPC CNE1 cell xenografts. Combination therapy had a synergic effect." @default.
- W2360702910 created "2016-06-24" @default.
- W2360702910 creator A5016770120 @default.
- W2360702910 creator A5023497175 @default.
- W2360702910 creator A5037783571 @default.
- W2360702910 creator A5069762731 @default.
- W2360702910 date "2007-07-01" @default.
- W2360702910 modified "2023-09-25" @default.
- W2360702910 title "[Anti-nasopharyngeal carcinoma effect in vivo and in vitro of Avastin and adenovirus-thymidine kinase suicide gene]." @default.
- W2360702910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17886683" @default.
- W2360702910 hasPublicationYear "2007" @default.
- W2360702910 type Work @default.
- W2360702910 sameAs 2360702910 @default.
- W2360702910 citedByCount "2" @default.
- W2360702910 countsByYear W23607029102016 @default.
- W2360702910 countsByYear W23607029102018 @default.
- W2360702910 crossrefType "journal-article" @default.
- W2360702910 hasAuthorship W2360702910A5016770120 @default.
- W2360702910 hasAuthorship W2360702910A5023497175 @default.
- W2360702910 hasAuthorship W2360702910A5037783571 @default.
- W2360702910 hasAuthorship W2360702910A5069762731 @default.
- W2360702910 hasConcept C104317684 @default.
- W2360702910 hasConcept C111599444 @default.
- W2360702910 hasConcept C126322002 @default.
- W2360702910 hasConcept C150903083 @default.
- W2360702910 hasConcept C153911025 @default.
- W2360702910 hasConcept C167734588 @default.
- W2360702910 hasConcept C190283241 @default.
- W2360702910 hasConcept C203014093 @default.
- W2360702910 hasConcept C207001950 @default.
- W2360702910 hasConcept C2522874641 @default.
- W2360702910 hasConcept C2776147627 @default.
- W2360702910 hasConcept C2777025900 @default.
- W2360702910 hasConcept C2777965375 @default.
- W2360702910 hasConcept C2778997737 @default.
- W2360702910 hasConcept C2779820661 @default.
- W2360702910 hasConcept C2781196997 @default.
- W2360702910 hasConcept C34981463 @default.
- W2360702910 hasConcept C502942594 @default.
- W2360702910 hasConcept C509974204 @default.
- W2360702910 hasConcept C553184892 @default.
- W2360702910 hasConcept C55493867 @default.
- W2360702910 hasConcept C71924100 @default.
- W2360702910 hasConcept C86803240 @default.
- W2360702910 hasConceptScore W2360702910C104317684 @default.
- W2360702910 hasConceptScore W2360702910C111599444 @default.
- W2360702910 hasConceptScore W2360702910C126322002 @default.
- W2360702910 hasConceptScore W2360702910C150903083 @default.
- W2360702910 hasConceptScore W2360702910C153911025 @default.
- W2360702910 hasConceptScore W2360702910C167734588 @default.
- W2360702910 hasConceptScore W2360702910C190283241 @default.
- W2360702910 hasConceptScore W2360702910C203014093 @default.
- W2360702910 hasConceptScore W2360702910C207001950 @default.
- W2360702910 hasConceptScore W2360702910C2522874641 @default.
- W2360702910 hasConceptScore W2360702910C2776147627 @default.
- W2360702910 hasConceptScore W2360702910C2777025900 @default.
- W2360702910 hasConceptScore W2360702910C2777965375 @default.
- W2360702910 hasConceptScore W2360702910C2778997737 @default.
- W2360702910 hasConceptScore W2360702910C2779820661 @default.
- W2360702910 hasConceptScore W2360702910C2781196997 @default.
- W2360702910 hasConceptScore W2360702910C34981463 @default.
- W2360702910 hasConceptScore W2360702910C502942594 @default.
- W2360702910 hasConceptScore W2360702910C509974204 @default.
- W2360702910 hasConceptScore W2360702910C553184892 @default.
- W2360702910 hasConceptScore W2360702910C55493867 @default.
- W2360702910 hasConceptScore W2360702910C71924100 @default.
- W2360702910 hasConceptScore W2360702910C86803240 @default.
- W2360702910 hasIssue "7" @default.
- W2360702910 hasLocation W23607029101 @default.
- W2360702910 hasOpenAccess W2360702910 @default.
- W2360702910 hasPrimaryLocation W23607029101 @default.
- W2360702910 hasRelatedWork W2014203648 @default.
- W2360702910 hasRelatedWork W2044380070 @default.
- W2360702910 hasRelatedWork W2088877272 @default.
- W2360702910 hasRelatedWork W2154629127 @default.
- W2360702910 hasRelatedWork W2173632145 @default.
- W2360702910 hasRelatedWork W2185480513 @default.
- W2360702910 hasRelatedWork W2350457825 @default.
- W2360702910 hasRelatedWork W2394354805 @default.
- W2360702910 hasRelatedWork W2957788206 @default.
- W2360702910 hasRelatedWork W3030315913 @default.
- W2360702910 hasVolume "42" @default.
- W2360702910 isParatext "false" @default.
- W2360702910 isRetracted "false" @default.
- W2360702910 magId "2360702910" @default.
- W2360702910 workType "article" @default.