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- W2360732055 abstract "Objective To assess the value of myocardial contrast echocardiography(MCE)with intermittent second harmonic technique and sulfur hexafluoride microbubbles(SonoVue)in evaluating myocardial microcirculation in acute myocardial ischemia and myocardial infarction. Methods Acute myocardial infarction was created in swine. SonoVue was injected before and 3h after the left anterior descending coronary artery(LAD)occlusion. The peak intensity(PI)and area under curve(AUC)were measured and compared between the normal and the ischemic myocardial area at short-axis view of left ventricle papillary muscle level. The infarct size assessed by MCE was compared with the pathologic specimen stained with Evan's blue. Results The peak intensity and area under curve in the ischemia area were significantly different with respect to the normal area(88.27±8.57 vs 48.26±4.36;1392.80±198.01 vs 646.68±55.86,P 0.001). The percentage of the negative contrast area determined by MCE was close correlated with that by Evan's blue stain(r=0.85,P0.05). Conclusions Intermittent second harmonic MCE with intravenous injection of sulfur hexafluoride microbubbles is a useful method to assess myocardial microcirculation perfusion,diagnose ischemia,and define myocardial infarct size." @default.
- W2360732055 created "2016-06-24" @default.
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- W2360732055 date "2006-01-01" @default.
- W2360732055 modified "2023-09-26" @default.
- W2360732055 title "Assessment of acute myocardial ischemia and infarction by myocardial contrast echocardiography with SonoVue" @default.
- W2360732055 hasPublicationYear "2006" @default.
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