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- W2360734399 abstract "While the incidence of gastric cancer has decreased worldwide in recent decades, the incidence of signet-ring cell carcinoma (SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer, which can be resected endoscopically in some cases and which has a better outcome than non-SRCC, and advanced gastric cancer, which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However, the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified, as the benefit of perioperative chemotherapy and the value of taxane-based chemotherapy are unclear. In this review we analyze recent data on the epidemiology, oncogenesis, prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer." @default.
- W2360734399 created "2016-06-24" @default.
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- W2360734399 creator A5073729469 @default.
- W2360734399 creator A5081179224 @default.
- W2360734399 date "2015-01-01" @default.
- W2360734399 modified "2023-10-04" @default.
- W2360734399 title "Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge" @default.
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- W2360734399 doi "https://doi.org/10.3748/wjg.v21.i40.11428" @default.
- W2360734399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4616218" @default.
- W2360734399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26523107" @default.
- W2360734399 hasPublicationYear "2015" @default.
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