Matches in SemOpenAlex for { <https://semopenalex.org/work/W2360744652> ?p ?o ?g. }
- W2360744652 endingPage "92" @default.
- W2360744652 startingPage "81" @default.
- W2360744652 abstract "The midbrain dopamine center comprises a key network for reward, salience, motivation, and mood. Evidence from various clinical and preclinical settings points to the midbrain dopamine circuit as an important modulator of pain perception and pain-induced anxiety and depression. This review summarizes recent findings that shed light to the neuroanatomical, electrophysiological and molecular adaptations that chronic pain conditions promote in the mesolimbic dopamine system. Chronic pain states induce changes in neuronal plasticity and functional connectivity in several parts of the brain reward center, including nucleus accumbens, the ventral tegmental area and the prefrontal cortex. Here, we discuss recent findings on the mechanisms involved in the perception of chronic pain, in pain-induced anxiety and depression, as well as in pain-killer addiction vulnerability. Several new studies also show that the mesolimbic dopamine circuit potently modulates responsiveness to opioids and antidepressants used for the treatment of chronic pain. We discuss recent data supporting a role of the brain reward pathway in treatment efficacy and we summarize novel findings on intracellular adaptations in the brain reward circuit under chronic pain states." @default.
- W2360744652 created "2016-06-24" @default.
- W2360744652 creator A5044436902 @default.
- W2360744652 creator A5090962514 @default.
- W2360744652 date "2016-12-01" @default.
- W2360744652 modified "2023-10-03" @default.
- W2360744652 title "Modulation of pain, nociception, and analgesia by the brain reward center" @default.
- W2360744652 cites W1455944166 @default.
- W2360744652 cites W1491978248 @default.
- W2360744652 cites W1504880924 @default.
- W2360744652 cites W1520279806 @default.
- W2360744652 cites W1545898428 @default.
- W2360744652 cites W1578507364 @default.
- W2360744652 cites W1581758663 @default.
- W2360744652 cites W1603857261 @default.
- W2360744652 cites W1630671347 @default.
- W2360744652 cites W1664843084 @default.
- W2360744652 cites W1675980378 @default.
- W2360744652 cites W1706861413 @default.
- W2360744652 cites W1822002712 @default.
- W2360744652 cites W1879409027 @default.
- W2360744652 cites W1896149175 @default.
- W2360744652 cites W1937097420 @default.
- W2360744652 cites W1964719865 @default.
- W2360744652 cites W1966351569 @default.
- W2360744652 cites W1967584838 @default.
- W2360744652 cites W1968562278 @default.
- W2360744652 cites W1971880874 @default.
- W2360744652 cites W1972883529 @default.
- W2360744652 cites W1974057366 @default.
- W2360744652 cites W1978660947 @default.
- W2360744652 cites W1979640215 @default.
- W2360744652 cites W1982326881 @default.
- W2360744652 cites W1982327643 @default.
- W2360744652 cites W1990080985 @default.
- W2360744652 cites W1991298548 @default.
- W2360744652 cites W1995265069 @default.
- W2360744652 cites W1996746265 @default.
- W2360744652 cites W1998026463 @default.
- W2360744652 cites W1998054425 @default.
- W2360744652 cites W1999460576 @default.
- W2360744652 cites W2001352609 @default.
- W2360744652 cites W2001775440 @default.
- W2360744652 cites W2010084449 @default.
- W2360744652 cites W2013368841 @default.
- W2360744652 cites W2013645250 @default.
- W2360744652 cites W2020613483 @default.
- W2360744652 cites W2022071529 @default.
- W2360744652 cites W2022561563 @default.
- W2360744652 cites W2023541866 @default.
- W2360744652 cites W2027022038 @default.
- W2360744652 cites W2027440324 @default.
- W2360744652 cites W2027677576 @default.
- W2360744652 cites W2028953043 @default.
- W2360744652 cites W2029985169 @default.
- W2360744652 cites W2032453542 @default.
- W2360744652 cites W2035421865 @default.
- W2360744652 cites W2038148370 @default.
- W2360744652 cites W2039012695 @default.
- W2360744652 cites W2042837986 @default.
- W2360744652 cites W2048076151 @default.
- W2360744652 cites W2048230914 @default.
- W2360744652 cites W2049933206 @default.
- W2360744652 cites W2050504180 @default.
- W2360744652 cites W2051288528 @default.
- W2360744652 cites W2052380247 @default.
- W2360744652 cites W2056552590 @default.
- W2360744652 cites W2056959797 @default.
- W2360744652 cites W2061350749 @default.
- W2360744652 cites W2061771087 @default.
- W2360744652 cites W2065296100 @default.
- W2360744652 cites W2065685204 @default.
- W2360744652 cites W2067535960 @default.
- W2360744652 cites W2069943000 @default.
- W2360744652 cites W2071358232 @default.
- W2360744652 cites W2071406159 @default.
- W2360744652 cites W2071815275 @default.
- W2360744652 cites W2075171107 @default.
- W2360744652 cites W2076092928 @default.
- W2360744652 cites W2076281802 @default.
- W2360744652 cites W2077234809 @default.
- W2360744652 cites W2078440247 @default.
- W2360744652 cites W2080362131 @default.
- W2360744652 cites W2081369904 @default.
- W2360744652 cites W2083800036 @default.
- W2360744652 cites W2085234856 @default.
- W2360744652 cites W2085963029 @default.
- W2360744652 cites W2088936071 @default.
- W2360744652 cites W2095088925 @default.
- W2360744652 cites W2098783566 @default.
- W2360744652 cites W2099753915 @default.
- W2360744652 cites W2111038577 @default.
- W2360744652 cites W2117629050 @default.
- W2360744652 cites W2117948779 @default.
- W2360744652 cites W2133656662 @default.
- W2360744652 cites W2133810101 @default.
- W2360744652 cites W2144534164 @default.
- W2360744652 cites W2148694444 @default.