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- W2360752451 abstract "Objective To evaluate the safety and efficacy of ascorbic acid in prevention of contrast-induced nephropathy in coronary heart disease (CHD) patients with diabetes mellitus (DM).Methods A single-center prospective randomized controlled trial was performed,96 CHD patients with DM were divided randomly into groups control (n=50,receiving only 0.9% sodium chloride solution for routine hydration) and intervention (n=46,based on routine hydration receiving vitamin C intravenous infusion,3.0 g,2～4 h before operation,and oral vitamin C,1.0 g,on day 1,2,respectively,after operation).The total dosage of intravenous and oral vitamin was 5.0 g.The renal function and the occurrence of adverse cardiac events were observed after operation.Results The incidence of contrast-induced nephropathy was lower in intervention group than in control,but the difference was not significant (6.5% vs 10.0%,P=0.540).No severe adverse cardiac events were noted in all patients during the research except 1 presenting with subacute stent thrombosis.Conclusion Short-term application of high-dosage vitamin C has a trend of lowering contrast-induced nephropathy in CHD patients with DM,but is not significantly different from control group.The efficacy of vitamin C in prevention of contrast-induced nephropathy needs large sample trials to confirm." @default.
- W2360752451 created "2016-06-24" @default.
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- W2360752451 date "2010-01-01" @default.
- W2360752451 modified "2023-09-27" @default.
- W2360752451 title "Prevention of Contrast-induced Nephropathy with Ascorbic Acid in Coronary Heart Disease Patients with Diabetes Mellitus" @default.
- W2360752451 hasPublicationYear "2010" @default.
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