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- W2360753316 abstract "OBJECTIVE To study the effects and mechanism of glibenclamide on the formation of foam cells in THP-1 cells.METHODS The THP-1 cells were cultured and differentiated into macrophages by phorbol myristate acetate(PMA).The macrophages were incubated with acetyled LDL(Ac-LDL) to generate foam cells.Glibenclamide was added in various doses on macrophages treated with or without Ac-LDL.The foam cells were determined by oil O staining.The acyl coenzyme A:cholesterol acyltransferase(ACAT) activity was measured by quantifying the incorporation of oleoyl CoA into cholesteryl esters.An enzymatic colorimetric assay was used to determine cell cholesterol mass.RESULTS The numbers of foam cells were decreased by glibenclamide.Glibenclamide significantly inhibited the activity of ACAT in THP-1 macrophages with or without Ac-LDL treatment.The cholesteryl esters(CE) mass decreased with the increasing doses of glibenclamide in macrophages with or without Ac-LDL treatment,the inhibiting effect was in a dose-dependant manner.CONCLUSION Glibenclamide inhibited the formation of foam cells.It may be the results of inhibits effect of activity of ACAT and the CE mass by glibenclamide." @default.
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- W2360753316 date "2007-01-01" @default.
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- W2360753316 title "Effects of glibenclamide on the formation of foam cells" @default.
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