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- W2360777785 abstract "Objective:To study the preparation of transforming growth factor (TGF-β_1) gelatin microspheres,and confirm whether controlled releasing system is appropriate for treating periodontal diseases.Methods:TGF-β_1 gelatin microspheres were prepared by improved emulsified cold-condensation method.Colorimetric MTT method was used to observe the proliferation of hPDLCs after different doses (1,5,10 mg/ml) of TGF-β_1 gelatin microspheres were added into the culture medium.Results:The diameter of gelatin microspheres was (10.28 ±2.24) μm on average.The encapsulation rate was 78.5%,and drug containing was 785 ng/g,94% of the drug was sustained-releasing within 7 days.TGF-β_1 promoted the proliferation of hPDLCs obviously.Conclusion:The TGF-β_1 gelatin microspheres can promote the proliferation of hPDLCs through a long period of controlled release of TGF-β_1.TGF-β_1 gelatin microspheres may be a promising drug dosage form which can be used to treat periodontal diseases." @default.
- W2360777785 created "2016-06-24" @default.
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- W2360777785 date "2009-01-01" @default.
- W2360777785 modified "2023-09-24" @default.
- W2360777785 title "Fabrication of TGF-β_1 gelatin microspheres and the effect on the proliferation of human periodontal ligament cells" @default.
- W2360777785 hasPublicationYear "2009" @default.
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