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- W2360778715 abstract "Objective To investigate the change of high mobility group box 1(HMGB1)expression in primary hepatic carcinoma(PHC)tissues,its induction mechanism,serum HMGB1 levels in PHC patients and its significance.Methods serum HMGB1levels were measured and analysed in 48 healthy control,38 chronic hepatitis,32 liver cirrhosis,23 secondary hepatocarcinoma and 39 PHC.HMGB1 gene expression was analysed in 11PHC tissues and their noncancerous tissues using RT-PCR.Using hepatocarcinoma cell SMMC-7721,the effect of hypoxia on HMGB1 mRNA expression and HMGB1release was observed.Results Serum HMGB1 levels in PHC patients(13.5±6.3μg/L)were significantly higher than that in healthy controls(3.9±1.4μg/L),and related with AFP concentration and TNM stage.HMGB1 mRNA expression in PHC tissues markedly raised.HMGB1 concentration in the culture supernatant increased at 3h,and HMGB1mRNA expression enhanced at 6h(P0.01),after SMMC-7721 cells were subjected to hypoxia culture.Conclusion HMGB1expression in PHC significantly increases,and hypoxia may be involved with its mechanism." @default.
- W2360778715 created "2016-06-24" @default.
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- W2360778715 date "2013-01-01" @default.
- W2360778715 modified "2023-09-23" @default.
- W2360778715 title "Increased HMGB1 expression in primary hepatic carcinoma and its mechanism" @default.
- W2360778715 hasPublicationYear "2013" @default.
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