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- W2360796115 abstract "AIM To establish a LC-MS/MS method for determination of rosiglitalizone in human serum. METHODS After addition of glibenclamide ( internal standard,IS) into serum sample,the analyte was processed by protein precipitation. The chromatographic separation was performed on Gemini 5u C18 110A (2.0 mm×50 mm,5 μm) column with a mobile phase of 10 mmol·L-1 of ammonium acetate aqueous solution-acetonitrile (40∶60,V∶V) at a flow rate of 0.3 mL·min-1. The protonated ions of analyte were detected in positive ionization by multiple reaction monitoring modes (MRM). The mass transition pairs of m/z 358.4→ 135.2 and m/z 494.5→369.2 were used to detect rosiglitalizone and internal standard,respectively,through MRM. RESULTS The linear concentration range of the calibration curves for rosiglitalizone was 2.5-640 μg· L-1. The lowest limit of quantitation was 2.5 μg·L-1. Within-day RSD and between-day RSD were less than 15%. CONCLUSION The method of LC-MS/MS is sensitive,accurate,specific and suitable for the pharmacokinetic study of rosiglitalizone." @default.
- W2360796115 created "2016-06-24" @default.
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- W2360796115 date "2009-01-01" @default.
- W2360796115 modified "2023-09-24" @default.
- W2360796115 title "Determination of rosiglitalizone in human serum by LC-MS/MS method" @default.
- W2360796115 hasPublicationYear "2009" @default.
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