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- W2360801490 abstract "Objective To investigate the mechanism of apoptosis of human umbilical vein endothelial cells (HUVECs) induced by aldosterone (ALD).Methods HUVECs were cultured in vitro and identified with immunofluorescence method.Flow cytometry assay (FCM) was applied to determine the apoptosis of HUVEC; mineralocorticoid receptor (MR) protein was detected with western blotting.Results (1) Compared with control group, the apoptosis rate induced by ALD was higher.(2) ALD induced the apoptosis of HUVECs in a dose dependent manner. (3) The above effect of ALD was decreased by spironolactone,a specific aldosterone receptor antagonist.(4) In addition, the expression of MR was up-regulated by ALD,which was partially antagonized by 10-6 mol/L spironolactone. Conclusion Mdosterone induces apoptosis of HUVECs probably by up-regulating the expression of MR." @default.
- W2360801490 created "2016-06-24" @default.
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- W2360801490 date "2010-01-01" @default.
- W2360801490 modified "2023-09-28" @default.
- W2360801490 title "Mineralocorticoid receptor mediated apoptosis of human umbilical vein endothelial cells induced by aldosterone" @default.
- W2360801490 hasPublicationYear "2010" @default.
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