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- W2360802280 abstract "Objective To observe the changes of orphanin receptor mRNA which was related with algesia in cornu dorsale medullae spinalis pre-and post-electroacupuncture and to investigate the therapeutical effect of electroacupuncture on neuralgia rats.Methods Thirty rats were divided into three groups,ten in each group.The control group was normal rats and growth freely.The rats in neuralgia group received the operation of chronic constriction injury on sciatic nerve.And electroacupuncture group were given electroacupuncture to treat for 30min at the seventh day after operation.Then sacrificed the rats in every group to get cornu dorsale medullae spinalis and to make frozen section.The changes of orphanin receptor mRNA which was related with algesia in cornu dorsale medullae spinalis were observed by hybridization in situ.Results Hyperalgesia appeared after ligating sciatic nerve of rats.Electroacupuncture could depress the hyperalgesia,and compared with neuralgia group,paw withdrawal latency of electroacupuncture group was significantly longer(P0.01).There were little positive cells of orphanin receptor mRNA inⅠ～Ⅵ layer of cornu dorsale medullae spinalis.The positive cells of orphanin receptor mRNA in neuralgia group on the seventh day after operation were more than those in control group(P0.001).There was significant difference between neuralgia group and electroacupuncture group in the number of positive cells of orphanin receptor mRNA in Ⅰ～Ⅱ layer and Ⅴ～Ⅵ layer(P0.05),but there was no difference between two groups in the number of positive cells of orphanin receptor mRNA in Ⅲ～Ⅳ layer(P0.05).Conclusion Therapeutical effect of electroacupuncture on neuralgia may be related with orphanin receptor in cornu dorsale medullae spinalis." @default.
- W2360802280 created "2016-06-24" @default.
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- W2360802280 date "2008-01-01" @default.
- W2360802280 modified "2023-09-23" @default.
- W2360802280 title "Effect of electroacupuncture on neuropathic pain rats" @default.
- W2360802280 hasPublicationYear "2008" @default.
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