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- W2360822609 abstract "Objective To investigate the efficacy of Kang Ning Capsule in combination with lamivudine(LAM) for therapy of HBeAg positive chronic hepatitis B(CHB). Methods The eligible patients with HBeAg positive CHB were split into 3 cohorts: one was treated with combination of Kang Ning Capsule plus LAM,the two others with Kang Ning Capsule or LAM monotherapy.The effect was evaluated according to the liver functions,fibrosis indices together with HBV DNA level at 0,6,12 months,respectively. Results The rates of ALT and AST normalization amounted to 80.0% 、87.5% and 77.5% 、87.5% in combination therapy cohort,which were significantly higher than that of monotherapy cohort at 6,12 months.And the fibrosis indices including HA,LN,PIIIP,IV-C had obvious improvement in 3 groups,moreover the rate was higher in combination therapy group than in monotherapy group at month 6.Furthermore,the clearance,seroconversion of HBeAg and HBV DNA undetectable rate was 42.5%,30.0% and 82.5% respectively in combination therapy group,which were also greater than in monotherapy group at month 12. Conclusion Present study suggests that Kang Ning Capsule plus LAM combination therapy was more efficacious than LAM or Kang Ning capsule monotherapy in HBeAg positive CHB patients." @default.
- W2360822609 created "2016-06-24" @default.
- W2360822609 creator A5006194974 @default.
- W2360822609 date "2011-01-01" @default.
- W2360822609 modified "2023-09-23" @default.
- W2360822609 title "EFFICACY OF KANG NING CAPSULE PLUS LAMIVUDINE COMBINATION FOR HBEAG POSITIVE CHRONIC HEPATITIS B PATIENTS" @default.
- W2360822609 hasPublicationYear "2011" @default.
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