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- W2360823255 abstract "Aim: To study the vascular structure changes induced by antibodies against the α_1-adrenoceptor. Methods: The models with the antibodies against α_1-adrenoceptor were made by immunizing Wistar rats with the second extracellular loop of α_1-adrenoceptor peptides. Spontaneous hypertension rats (SHR) and normal Wistar rats served as control. The blood pressure(BP) and antibody titers were determined using tail-cuff method and ELISA,respectively.The pathological changes of aorta and mesentery were observed under microscope.c-jun and c-fos expressions in aorta were measured by using immunohistochemistry. Results: At 2 weeks after immunity,the antibody titers in immunity group began to increase and remained a higher level through out the experiment;BP in immunity group and control group had no significant difference but lower than that in SHR group;the thickness of aorta vascular wall in immunity group was higher than that in control group((0.382±0.075) mm vs (0.297±0.009) mm),and the ratio of vascular wall thickness to lumen thickness in immunity group was higher,too.Compared with control group and SHR group,in immunity group,the mitochondria of smooth muscle cells and collagen fibril in interstitum both increased;the expression of c-jun protein was higher than that of control group.Conclusion: The antibodies against α_1-adrenoceptor could contribute to vascular structure changes in rats by increasing c-jun expression of vascular smooth muscle cells, and may play a particular role in hypertension." @default.
- W2360823255 created "2016-06-24" @default.
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- W2360823255 date "2005-01-01" @default.
- W2360823255 modified "2023-09-24" @default.
- W2360823255 title "Antibodies against the α_1-adrenoceptor mediate vascular structure in rats" @default.
- W2360823255 hasPublicationYear "2005" @default.
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