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- W2360826000 abstract "Objective To investigate the effects of in situ transfection of α-melanocyte stimulating hormone (MSH) gene into donor heart on the allograft rejection in mice. Methods The hearts from Balb/c donors were transfected in situ by rAAV carrying green fluorescent protein (GFP) and α-MSH genes (rAAV-α-MSH) or rAAV carrying GFP alone (rAAV-GFP),and then transplanted to the allogeneic recipients (C57BL/6). The allograft survival time was observed. The in situ expression of α-MSH in the allografts was examined at different time-points after transplantation. The levels of cytokines and chemokines in the allografts were examined at day 7 after transplantation. Results α-MSH gene could be efficiently transferred into donor heart by rAAV vector. The survival time (16.3±2.21) d of α-MSH gene-transfected cardiac graft was prolonged compared with those transfected by rAAV-GFP (7.0±0.33) d or PBS control (7.0±2.23) d. In rAAV-α-MSH transfected cardiac graft,Th1 cytokines (IL-2 and IFN-α) and chemokines (RANTES and MCP-1) decreased,while Th2 cytokines (IL-4 and IL-10) increased at day 7 after transplantation. Conclusion Direct delivery of rAAV-α-MSH into the allografts can facilitate the deviation from Th1 to Th2 response and reduce the expression of chemokines so that significantly prolongs the survival of allografts." @default.
- W2360826000 created "2016-06-24" @default.
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- W2360826000 date "2008-01-01" @default.
- W2360826000 modified "2023-10-11" @default.
- W2360826000 title "In situ transfection of α-melanocyte stimulating hormone gene into donor heart prolongs the survival of allogeneic cardiac graft in mice" @default.
- W2360826000 hasPublicationYear "2008" @default.
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