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- W2360832787 abstract "Objective To investigate the effects of different antihypertensive therapies on concentrations of plasma matrix metallopeptidase 9(MMP-9) and tissue inhibitor of metalloproteinases 1(TIMP-1) in hypertensive patients with left ventricular hypertrophy(LVH).Methods Fifty-one hypertensive patients with LVH [male 28,female 23,average age (61.8±7.0)] were randomly assigned to receive low-dose amlodipine(2.5 mg/d)plus telmisartan(40 mg/d)[male 14,female 12,average ages(62.2±6.8)] or low-dose amlodipine(2.5 mg/d)plus compound amiloride(0.5 tablet/d)[male 14,female 11,average ages(63.4±7.3)].All the patients were followed-up for 1 year.Baseline and one year left ventricular mass index (LVMI) were examined,and the concentrations of plasma MMP-9 and TIMP-1 were detected respectively.Fifty-two healthy individuals were taken as control.Results The concentrations of plasma MMP-9 and TIMP-1 in hypertensive LVH patients were significantly higher than those in control (all P0.05).Mean blood pressure,LVMI,the plasma MMP-9 and TIMP-1 at baseline were similar between amlodipine with telmisartan and amlodipine with amiloride group,they are (153.2±8.9)/(95.2±4.8) vs (151.3±8.7)/(94.8±3.3) mm Hg,(129.5±16.3) vs (127.6±17.3) g/m2,(81.8±23.4) vs (80.3±22.2) and(429.1±43.5) vs (449.2±50.6)μg/L respectively.After 1 year treatment,in amlodipine with telmisartan group and amlodipine with amiloride group,the blood pressure was reduced to (126.0±9.9)/(73.6±7.2) and (129.8±5.5)/(79.2±5.3)mm Hg,LVMI to(91.7±16.9) and(104.7±16.3)g/m2,respectively.The concentrations of plasma MMP-9 and TIMP-1 were (65.3±19.9)vs (68.1±19.4),(488.2±44.4) vs (486.1±59.1) μg/L respectively,which differ significantly from baseline (all P0.05).Conclusion CCB-based antihypertensive combination therapy could reverse LVH though decreasing blood pressure and altering MMP/TIMP enzyme systems." @default.
- W2360832787 created "2016-06-24" @default.
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- W2360832787 date "2010-01-01" @default.
- W2360832787 modified "2023-09-23" @default.
- W2360832787 title "Effects of Amlodipine Combined with Telmisartan or with Amiloride on Plasma Matrix Metallopeptidase 9 and Tissue Inhibitor of Metalloproteinases 1 in Hypertensive Patients with Left Ventricular Hypertrophy" @default.
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