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- W2360841436 abstract "Objective To assess Bmi-1 expression in resectable non-small cell lung cancer(NSCLC) in association with p16INK4a and p14ARF(=human p19ARF).Methods Sections were obtained from previous 10%-formalin-fixed and paraffin-embedded tissues.The protein expressions of p16INK4a and p14ARF were detected in 123 NSCLC samples by immunohistochemistry(S-P method) at first.Then the p16INK4a and p14ARF negative co-expression cases and positive co-expression cases were selected.These samples were divided into two groups,namely(p14+p16) negative group and(p14+p16) positive group,respectively.The protein expression of Bmi-1 was detected by immunohistochemistry.Results Negative expression of p16INK4a was detected in 50(40.65%) of 123 NSCLC cases.However,73 cases showed positive immunohistochemical result.Negative expression of p14ARF was detected in 89(72.36%) of 123 NSCLC cases.However,34 cases showed positive immunohistochemical result.The difference was significant for the negative rates of p16INK4a and p14ARF expressions(P0.01).The p16INK4a and p14ARF negative co-expression cases and positive co-expression cases were 39 and 24,respectively.Tumors with moderate or strong Bmi-1 expression were more likely to have low levels of p16INK4a and p14ARF.Similarly,tumors negative for both,p16INK4a and p14ARF,exhibit moderate-strong Bmi-1 staining.Conclusion The inverse correlation of Bmi-1 and the INK4A-ARF locus protein expressions supports a possible role for Bmi-1 misregulation in lung carcinogenesis." @default.
- W2360841436 created "2016-06-24" @default.
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- W2360841436 date "2008-01-01" @default.
- W2360841436 modified "2023-09-23" @default.
- W2360841436 title "The Bmi-1 oncoprotein overexpression in non-small cell lung cancer is correlated with INK4A-ARF locus downexpression" @default.
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