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- W2360843791 abstract "Objective To observe the expression of dystrophin on the cell surface membrane of fibers examined by immunofluorescent technique for diagnosing and classifying Duchenne muscular dystrophy(DMD),Becker muscular dystrophy(BMD) and carrier of DMD.Met-hods Twenty-seven cases(1 to 11 years old) and one carrier of DMD were detected by immunofluorescent technique with 3 antibodies against different domain of dystrophin-dys-R(rod domain),dys-C(C-terminus),dys-N(N-terminus) for analyzing the dystrophin located in skeletal muscle cell membrane.Results Ringed positive staining stripe around muscle fibers were found in all the the normal individuals.Negative result of staining was seen in 20 cases of DMD patients,positive immunofluorescent staining reaction were seen in single fiber or a small cluster of fibers in 3 patients,discontinuous or a patchy positive staining pattern were showed in 3 BMD patients.In the carrier of DMD,the expression of dystrophin was markedly reduced.Conclusions A good method was explored in this study,in which 3 antibodies against different domain of dystrophin were used to detect the expression of dystrophin by immunofluorescent technique.This method can be effectively used in diagnosing DMD patients,BMD patients,and carriers of DMD." @default.
- W2360843791 created "2016-06-24" @default.
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- W2360843791 date "2009-01-01" @default.
- W2360843791 modified "2023-09-26" @default.
- W2360843791 title "Dystrophin Detection by Immunofluorescent Technique for Diagnosing Duchenne Muscular Dystrophy/Becker Muscular Dystrophy and Duchenne Muscular Dystrophy Carrier" @default.
- W2360843791 hasPublicationYear "2009" @default.
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